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多囊肾为什么会发生慢性肾功能衰竭?

来源:[标签:来源] | 发布时间:2011-07-23 10:48:26 | www.chinesejk.com
多囊肾发生慢性肾功能衰竭的机理,除因囊肿压迫、取代正常肾组织外,尚有以下两个因素:①非囊肿组织(小管、间质、血管)的缺血、硬化和/或炎症、纤维化;②进行性功能肾单位的丧失引起剩余的正常肾单位的高灌注、高滤过以及促肾生长因子的产生均促进肾单位的进一步破坏。因此,邻近区域的状况决定了肾功能损害的发展速度。高血压和尿路感染也是影响肾功能损害发展速度的因素。同一家族内发展至尿毒症的时限相似。

(编辑:小鱼 )

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