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继发性铁粒幼细胞贫血

来源:[标签:来源] | 发布时间:2011-06-09 19:41:49 | www.chinesejk.com
某些药物和化学毒物可以引起继发性SA,如抗结核药(异菸肼,环丝氨酸,吡嗪酰胺),氯霉素,烷化剂(环磷酰胺,氮芥,马法仑),酒精、铅等。SA还可继发于:造血系统疾病(溶血性贫血,骨髓瘤,真性红细胞增多症,骨髓纤维化等),恶性肿瘤(淋巴瘤,前列腺癌等),慢性炎症(类风湿关节炎,结节性多动脉炎等),代谢内分泌疾病(粘液性水肿,甲状腺机能亢进,尿毒症,血卟啉病等)。上述继发性SA的机理不明。继发性SA时环形铁粒幼细胞较少,红细胞无效生成也较轻微。一旦停用有关药物,脱离化学毒物接触或控制原发病,SA多能随之消失。使用维生素B6可能加速贫血的纠正。

(编辑:小珊 )

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